The Pediatric Critical Care Medicine Website

Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis. Shu Wen Toh T, R R P, Ho KHY, Sultana R, Couban R, Choong K, Lee JH. JAMA Netw Open. 2024 Aug 1;7(8):e2426225. PMID: 39110460 [abstract]

Management Changes After Echocardiography Are Associated With Improved Outcomes in Critically Ill Children. Ip PYF, Periasamy U, Staffa SJ, Zurakowski D, Kantor DB. Pediatr Crit Care Med. 2024 Aug 1;25(8):689-698. PMID: 38591948 [abstract; full-text (pdf 1.6 M)]

Race, Ethnicity, and Pediatric Postsurgical Mortality: Current Trends and Future Projections. Nafiu OO, Mpody C, Aina TA, Ehie O, Tobias JD, Best AF. Pediatrics. 2024 Aug 1;154(2):e2024065906. PMID: 39069821 [abstract] {Editor note: though not specific to Pediatric Critical Care Medine, highlighting this manuscript is relevant to all of us...}

Medical Complexity, Language Use, and Outcomes in the Pediatric ICU. Pilarz MS, Bleed E, Rodriguez VA, Daniels LA, Jackson KL, Sanchez-Pinto LN, Foster CC. Pediatrics. 2024 Jun 1;153(6):e2023063359. PMID: 38747049; [abstract]

NICHD Data and Specimen Hub (DASH)

The NICHD also wishes to announce that seven Collaborative Pediatric Critical Care Research Network (CPCCRN) studies have been archived and released in the NICHD Data and Specimen Hub (DASH):

Development of a Quantitative Functional Status Scale (FSS) for Pediatric Patients
The Critical Illness Stress-induced Immune Suppression Prevention (CRISIS) Trial
Cortisol Quantification Investigation: Prospective, Observational Study Comparing Free versus Total Serum Cortisol in PICU Patients
Critical Asthma Mortality and Morbidity Planning Study (CAMMP)
Trichotomous Outcome Prediction in Critical Care (TOPICC)
Bleeding and Thrombosis During ECMO (BATE).
Measuring Opioid Tolerance Induced by Fentanyl (or Other Opioids) (MOTIF)

All interested investigators are encouraged to explore these and other studies archived in DASH that are available for secondary analysis. In addition to accessing study data and documents, DASH also serves as a portal for requesting access to biospecimens that are available for some studies. Please feel free to share this information with other investigators and colleagues who may be interested in learning more about DASH to archive their studies or to obtain data and biospecimens for their own research.

For questions regarding any of these issues, please feel free to contact Tessie October, MD, MPH at tessie.october@nih.gov or Tammara Jenkins, MSN, RN at tjenkins@mail.nih.gov

Multisite Clinical Research: Leveraging Network Infrastructure to Advance Research for Women, Children, Pregnant and Lactating Individuals, and Persons with Disabilities (U01 Clinical Trial Optional) (PAR-23-037)

• The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has issued a Funding Opportunity Announcement to invite applicants for multisite clinical trials and observational studies developed in conjunction with NICHD Networks that will be conducted using NICHD-supported Network infrastructure.   The goal of this FOA is to operationalize the previously reported NICHD guiding principles for multisite clinical trials delineated in Notice NOT-HD-19-034.
• Consequently, multisite clinical trials and observational studies conducted by and within the participating NICHD-supported Clinical Research Networks will be submitted as investigator-initiated, multi-Principal Investigator (PI) grant applications by any qualified investigator in the extramural community (including NICHD Network investigators) in conjunction with the respective NICHD Network Data Coordinating Center (DCC).
• Prior to application submission, all proposals must first undergo a rigorous pre-application process.  For additional information about this pre-application process, refer either to the FOA (PAR-23-037) or the following NICHD website:  Pre-Application Process for NICHD Network Multisite Clinical Research | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development (nih.gov)
• The first full protocol submission due date June 5, 2023, after which submissions will follow NIH Standard Submission Dates.  The PAR expires May 8, 2026.
• For specific questions not addressed in the FOA or website, please email the Scientific Contact for the FOA, Dr. Robert Tamburro, at NICHD-Network-ClinicalResearch@nih.gov

For questions regarding any of these issues, please feel free to contact Tessie October, MD, MPH at tessie.october@nih.gov or Tammara Jenkins, MSN, RN at tjenkins@mail.nih.gov

A survey regarding fluid management from Chloe Braun, Pediatric Critical Care fellow at UAB Birmingham, is here...